A first-in-human trial on the safety and immunogenicity of COVID-eVax, a cellular response-skewed DNA vaccine against COVID-19Clinical Trial Published on 2023-03-012023-07-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), [키워드] COVID-19 COVID-eVax DNA vaccine Immunogenicity. SARS-CoV-2 T cell response [DOI] 10.1016/j.ymthe.2022.12.017 PMC 바로가기 [Article Type] Clinical Trial
Safety and immunogenicity of the bi-cistronic GLS-5310 COVID-19 DNA vaccine delivered with the GeneDerm suction deviceArticle Published on 2023-03-012023-07-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), [키워드] DNA vaccine ORF3a persistence of immune response SARS-CoV-2 Suction mediated in vivo transfection T cell immune response. [DOI] 10.1016/j.ijid.2022.12.037 PMC 바로가기
Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Evaluation of dendritic cell-targeting T7 phages as a vehicle to deliver avian influenza virus H5 DNA vaccine in SPF chickensArticle Published on 2022-12-152023-06-03 Journal: Frontiers in Immunology [Category] Fulltext, 조류인플루엔자, [키워드] Avian Influenza dendritic cell-targeting. DNA vaccine SPF chicken T7 phage [DOI] 10.3389/fimmu.2022.1063129 PMC 바로가기
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity vaccine immunogenicity. variants of concern viral entry viral infectivity VoC VOCs was determined weakened [DOI] 10.1038/s41423-022-00924-8 PMC 바로가기
Strategy of developing nucleic acid-based universal monkeypox vaccine candidatesReview Published on 2022-10-272023-06-09 Journal: Frontiers in Immunology [Category] Fulltext, 원숭이두창, [키워드] DNA vaccine Monkeypox virus MPXV mRNA vaccine pandemic universal vaccine. [DOI] 10.3389/fimmu.2022.1050309 PMC 바로가기 [Article Type] Review
A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cellsArticle Published on 2022-09-022022-11-15 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, 변종, 비임상, 진단, [키워드] antibody Beta contagious cross-reactive Delta DNA vaccine domain evade functional Human human ACE2 receptor Immunity induce lethal disease lethal infection membrane mice neutralized neutralizing antibody New observation omicron pandemic priming PROTECT Protective SARS-CoV SARS-CoV vaccine SARS-CoV-2 Spike protein T cell T cells the SARS-CoV-2 Vaccine Vaccine development Vaccines variant variants virus WHO [DOI] 10.15252/emmm.202215821 PMC 바로가기
Preclinical study of a DNA vaccine targeting SARS-CoV-2Article Published on 2022-09-012023-07-09 Journal: Current research in translational medicine [Category] COVID19(2023년), [키워드] adjuvant antibody COVID-19 DNA vaccine neutralization activity T cell activation. [DOI] 10.1016/j.retram.2022.103348 PMC 바로가기
Immunogenicity of candidate SARS-CoV-2 DNA vaccines based on the spike protein스파이크 단백질을 기반으로 한 후보 SARS-CoV-2 DNA 백신의 면역원성Article Published on 2022-08-012022-09-12 Journal: Virology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Antigen candidate caused Cell-mediated immune responses control group coronavirus Coronavirus disease 2019 cytokine expression DNA DNA vaccine dose elevated evaluated full-length full-length S group highest humoral immune responses IgG immune response immunized immunogenicity mice NAb titer NAbs neutralizing antibody Prevent Protein public health S protein SARS-CoV-2 SARS-COV-2 infection significantly significantly increased spike spike protein. T-cell Response the spike protein vaccination vaccination schedule Vaccine [DOI] 10.1016/j.virol.2022.06.006 PMC 바로가기 [Article Type] Article
Adverse events following COVID-19 vaccination: A systematic review and meta-analysisResearch article Published on 2022-08-012022-10-05 Journal: International immunopharmacology [Category] 비임상, 임상, [키워드] 95% CI Adverse adverse event adverse events Adverse reaction approved benefit calculated clinical trial control group COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines database DNA DNA vaccine Efficacy Efficacy and safety event greater immunization Inactivated vaccine ISI Local Meta-analysis mRNA mRNA vaccine Occurrence protein subunit vaccine raised Result risk Safety SARS-CoV-2 searched systematic review systemic adverse reaction systemic and local vaccination Vaccine Vaccines WHO [DOI] 10.1016/j.intimp.2022.108906 [Article Type] Research article